منابع مشابه
Elevated expression of MITF counteracts B-RAF–stimulated melanocyte and melanoma cell proliferation
The protein kinase B-RAF is a human oncogene that is mutated in approximately 70% of human melanomas and transforms mouse melanocytes. Microphthalmia-associated transcription factor (MITF) is an important melanocyte differentiation and survival factor, but its role in melanoma is unclear. In this study, we show that MITF expression is suppressed by oncogenic B-RAF in immortalized mouse and prim...
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BACKGROUND UV-B-exposed keratinocytes secrete various paracrine factors. Among these factors, basic fibroblast growth factor (bFGF) stimulates the proliferation of melanocytes. Ginsenosides, the major active compounds of ginseng, are known to have broad pharmacological effects. In this study, we examined the antiproliferative effects of ginsenosides on bFGF-induced melanocyte proliferation. M...
متن کاملThe biology of melanocyte and melanocyte stem cell.
The melanocyte stem cells of the hair follicle provide an attractive system for the study of the stem cells. Successful regeneration of a functional organ relies on the organized and timely orchestration of molecular events among distinct stem/progenitor cell populations. The stem cells are regulated by communication with their specialized microenvironment known as the niche. Despite remarkable...
متن کاملThe Melanocyte Model
The effect of various agents that cause metaphase arrest in dividing cells was studied on the rapid reversible darkening of frog skin under the influence of melanocyte-stimulating hormone (MSH). Darkening is due to dispersion of melanin granules in melanocytes and is thought to be accompanied by a gel-to-sol cytoplasmic transformation. After subsequent washing the skin lightens, with aggregatio...
متن کاملMelanocyte stem cells∗
Pigmentation of mammalian hairs is mediated by specialized pigment-producing cells referred as melanocytes. Hair pigmentation is tightly linked with hair regeneration cycles, where melanocytes proliferate and differentiate during the hair growth phase, but depleted by apoptosis during the regression phase. This periodical appearance of melanocytes is maintained by a small pool of immature stem ...
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ژورنال
عنوان ژورنال: Experimental Dermatology
سال: 2006
ISSN: 0906-6705,1600-0625
DOI: 10.1111/j.1600-0625.2006.00493.x